European Research Council

Selective Carbon-Carbon bond Activation: A Wellspring of Untapped Reactivity

The distant and selective activation of unreactive C−H and C−C bonds is one of important challenges in organic chemistry. In recent years, the development of remote functionalization has received a growing interest as it allows for the activation of rather challenging C−H and C−C bonds distant from the initiation point by means of a “metal-walk.

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Selective Functionalization of Unsaturated Hydrocarbons

C–H functionalization has represented a paradigm shift from the standard logic of organic synthesis. Instead of focusing on orchestration of selective reactions at functional groups, C-H activation reactions have relied on the controlled functionalization of specific C–H bonds, even in the presence of more reactive functional groups.

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