European Research Council

The distant and selective activation of unreactive C−H and C−C bonds is one of important challenges in organic chemistry. In recent years, the development of remote functionalization has received a growing interest as it allows for the activation of rather challenging C−H and C−C bonds distant from the initiation point by means of a “metal-walk.

C–H functionalization has represented a paradigm shift from the standard logic of organic synthesis. Instead of focusing on orchestration of selective reactions at functional groups, C-H activation reactions have relied on the controlled functionalization of specific C–H bonds, even in the presence of more reactive functional groups.